Spravato, also known as esketamine, is a prescription medication used as a nasal spray for the treatment of treatment resistant depression. Here are a few things you should know about Spravato:
- Mechanism of action: Spravato is an NMDA receptor antagonist, which means it works by modulating the release of certain neurotransmitters in the brain, including glutamate. It is believed that this modulation helps to restore balance in the brain and improve depressive symptoms.
- Administration and dosage: Spravato is administered as a nasal spray in a healthcare setting, and each dose is individually packaged. Initially, it is given twice per week for the first four weeks, then the frequency is reduced to once a week or every two weeks, depending on the response. Typically, the dose is gradually increased over time. A healthcare professional will guide you through the administration process.
- Safety precautions: Spravato may cause sedation, dizziness, dissociation, and increased blood pressure. Due to these potential side effects, after receiving a dose of Spravato, you will be required to stay under the observation of a healthcare provider for at least two hours to ensure your safety. You should not drive or operate machinery on the day of treatment.
- Contraindications: Spravato is contraindicated in individuals with aneurysmal vascular disease, bleeding disorders, intracranial hemorrhage, or hypersensitivity to esketamine. It is advised to inform your healthcare provider about any existing medical conditions you have or medications you are taking before starting Spravato.
- Effectiveness: Clinical trials have shown that Spravato can be effective in treating treatment-resistant depression, which means depression that has not responded to other conventional treatments. However, individual responses may vary, and it may take a few weeks or more before the full effects are felt.
- Additional therapies: Spravato is typically used as an adjunctive treatment to an oral antidepressant medication in a comprehensive treatment plan. It is not meant to replace other depression medications completely but rather enhance their effectiveness.
- Cost and insurance coverage: The cost of Spravato can be significant, and insurance coverage may vary. It is advised to contact your insurance provider or healthcare provider to determine coverage and potential financial assistance programs.
It is essential to discuss the potential benefits and risks of Spravato (esketamine nasal spray) with your healthcare provider to determine if it is an appropriate treatment option for you.
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This article is general information, not medical advice. It cannot diagnose you and is not a substitute for an evaluation by a licensed clinician.